Bcl-2 Rabbit Antibody

英文名:Rabbit Monoclonal IgG
Cas号:
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别 名
Cas号
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分子式
分子量
产品参数 【产品介绍】The Bcl-2 family of proteins regulate
apoptosis by controlling mitochondrial permeability
a n d release of cytochrome c. Bcl-2 is an
anti-apoptotic protein that resides in the
outer mitochondrial wall a n d inhibits release
of cytochrome c (1). Over-expression of Bcl-2 has been
shown to promote cell survival by suppressing apoptosis.
It has been documented that bcl-2 becomes deregulated
in tum o r cells as a result of translocation into
the immunoglobulin heavy-chain locus a n d is theref
o r e activated in B cell malignancies (2). It has also
been shown that post-translational modification of
Bcl-2, phosph o r ylation at serine 70, may be required
to render its full a n d / o r enhanced
anti-apoptotic effect (3, 4).


WB: 1:500
IHC: 1:100-1:200
ICC: 1:00
Flow Cytometry: 1:200
IP: 1:50

A. Western blot analysis of Jurkat cell lysate
using anti-Bcl-2 RabMab (Cat#1017-1), 1:1,000 dilution.

B. Immunohistochemical analysis of paraffin-embedded
human breast carcinoma using anti-BCL-2 Rab Mab (Cat#1017-1).

C. Flow cytometric analysis of permeabilized Jurkat
cells using anti-Bcl-2 RabMAb (red)(catalog #1017-1)
o r a rabbit IgG (negative) (green).
性状 【反应特异性】Human , Mouse
【克隆 ID】E17
【用途】WB , IHC , ICC , FC , IP
【抗原分子量】26 kDa
贮存
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