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Btk Phospho (pY551)
英文名：Rabbit Monoclonal IgG
Cas号：
Cas号：
检测信息查询
| 货号 | 规格 | 货期 | 库存 | 价格 | 会员价 | 订购 |
| 1308113381-100ul | 现货 | 0 | ￥0 | 请登录 |
| 别 名 | Bruton tyrosine kinase, Agammaglobulinaemia tyrosine kinase, ATK, B-cell progenit o r kinase, BPK |
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| 产品参数 | 【产品介绍】Btk (Bruton tyrosine kinase also known as BPK
o r ATK) is a member of the TEC family of non-recept o r protein tyrosine kinase which includes Bmx, Itk a n d TEC. Btk is composed of a pleckstrin domain, an SH3 a n d SH2 domain, a catalytic kinase domain a n d a TEC homology domain (1). BTK plays a crucial role in B cell activation a n d development (2). Similar to Etk-TNFR2 interaction, Btk interacts with Fas, a member of the TNFR family involved in apoptosis in a lig a n d -independent manner (3) Btk can be activated through intramolecular autophosph o r ylation at tyrosine 551 a n d that Btk autophosph o r ylation is required f o r Btk catalytic functions (4). Mutations in the Btk gene have been linked to severe developmental blocks in human B-cell ontogeny leading to X-linked agammaglobulinemia (XLA). Patients with this disease are unusually prone to bacterial infection but not to viral infection (5). WB: 1:2,000 ICC: 1:100-250 A. Western blot analysis of anti-Btk phospho (pY551) RabMAb (cat. #1685-1), 1:2,000 dilution A: K562 cell lysate non-treated B: K562 cell lysate + Pervanadate C: Jurkat cell lysate non-treated D: Jurkat cell lysate + Pervanadate |
| 性状 | 【反应特异性】Human
【克隆 ID】EP267Y 【用途】WB , ICC 【抗原分子量】74 kDa |
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