Cytokeratin 16 (KRT16)

英文名:Rabbit Monoclonal Antibody
Cas号:
检测信息查询
货号 规格 货期 库存 价格 会员价 订购
1308113484-100ul 现货 0 ¥0 请登录
- +
偏远地区如新疆西藏宁夏甘肃等地可能无法运送液体,下单前请联系客服。
别 名 KRT16 antibody, CK16 antibody, FNEPPK antibody, K16 antibody, K1CP antibody, KRT16A antibody, NEPPK antibody, Keratin, type I cytoskeletal 16 antibody, Keratin-16 antibody
Cas号
M D L
分子式
分子量
产品参数 【产品介绍】The human type I keratin 16 (CK16)
is constitutively expressed in a number of
complex epithelial tissues, including skin, but is
better known for its induction under conditions
favoring enhanced proliferation or abnormal
differentiation, including wound healing, psoriasis,
and cancer (1). CK16 is expressed in
suprabasal interfollicular epidermis in wound healing
and other pathological conditions associated
with hyperproliferation, such as psoriasis and are
induced when keratinocytes are cultured in vitro.
However, CK16 is also constitutively expressed in
normal suprabasal mucosal and palmoplantar
keratinocytes (2). Pachyonychia congenita (PC) is a group
of inherited ectodermal dysplasias, the
characteristic phenotype being hypertrophic nail
dystrophy. The PC-1 phenotype may be distinguished by
the absence of the epidermal cysts found in PC-2, and it
has been shown to be caused by mutations in either
keratin K16 or its expression partner, the K6a isoform
of K6. Mutations in K16 have also been shown to cause
a milder related phenotype, focal
non-epidermolytic palmoplantar keratoderma (3).


Recommended Applications

WB, IHC, ICC, IP, FC
Applications and Recommended Dilution Factors

WB: 1:2000 - 10,000
IHC: 1:100 - 250
ICC: 1:100 - 250
IP: 1:10 - 100
FC: 1:10 - 100
Species Reactivity *

Human

*Cross reactivity determined by western blot only.

Products Data

A. Western blot analysis on HaCat cell lysate
using anti-CK-16 RabMAb (cat. # 2142-1),
dilution 1:10,000.

B. Immunohistochemical analysis of paraffin-embedded
human squamous cervical carcinoma using anti-CK16
RabMAb (cat. #2142-1).

Specificity

A synthetic peptide corresponding to residues near
the N-terminus of human CK-16 was used as an immunogen.
性状 【反应特异性】Human
【克隆 ID】EP1615Y
【用途】WB , IHC , ICC , FC , IP
【抗原分子量】48kDa
贮存 Storage Condition and Buffer Store at -20 °C. Buffer: 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA. Stable for 12 months from date of receipt.
本网站销售的所有产品仅用于工业应用或者科学研究等非医疗目的,不可用于人类或动物的临床诊断或者治疗,非药用,非食用。
X
QQ