DAP12 (TYROBP)

英文名:Rabbit Monoclonal Antibody
Cas号:
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别 名 TYROBP antibody, DAP12 antibody, KARAP antibody, PLOSL antibody, TYRO protein tyrosine kinase-binding protein antibody, DNAX-activation protein 12 antibody, Killer-activating receptor-associated protein antibody
Cas号
M D L
分子式
分子量
产品参数 【产品介绍】DAP12 is a transmembrane signaling
polypeptide which contains an immunoreceptor
tyrosine-based activation motif (ITAM) in its
cytoplasmic domain. It may associate with the
killer-cell inhibitory receptor (KIR) family of
membrane glycoproteins and may act as an activating
signal transduction element. DAP12 may bind zeta-chain
(TCR) associated protein kinase 70kDa (ZAP-70) and
spleen tyrosine kinase (SYK) and play a role in
signal transduction, bone modeling, brain myelination,
and inflammation. Mutations within this protein have
been associated with polycystic
lipomembranous osteodysplasia with
sclerosing leukoencephalopathy (PLOSL), also known
as Nasu-Hakola disease. Its putative receptor,
triggering receptor expressed on myeloid cells 2
(TREM2), also causes PLOSL (1).


Recommended Applications

WB, ICC
Applications and Recommended Dilution Factors

WB: 1:1,000 - 10,000
ICC: 1:250 - 500
Species Reactivity *

Human

*Species cross-reactivity is based on WB analysis.

Products Data

Western blot analysis on (A) peripheral blood
leukocytes, (B) human placenta, and (C) peripheral
blood mononuclear cell lysates using anti-DAP12
RabMAb (cat. #5168-1).

Specificity

A synthetic peptide corresponding to residues in human
DAP12 was used as an immunogen.

性状 【反应特异性】Human
【克隆 ID】EPR5173
【用途】WB , ICC
【抗原分子量】12kDa
贮存 Storage Condition and Buffer Store at -20 °C. Antibody buffer, 0.01% sodium azide, 50% Glycerol and 0.05% BSA. Stable for 12 months from date of receipt
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