ERG DyLight® 488

英文名:Rabbit Monoclonal Antibody
Cas号:
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别 名 ERG antibody, erg-3 antibody, p55 antibody, Transcriptional regulator ERG antibody, Transforming protein ERG antibody
Cas号
M D L
分子式
分子量
产品参数 【产品介绍】Transcriptional Regulator ERG belongs to the
ETS family that is involved in the regulation of a
wide variety of cellular and developmental processes
(1). This family of transcription factors
contains approximately 30 members that share a
highly conserved DNA-binding domain (ETS domain) (2, 3)
and differs from each other in other domains (such
as absence or presence of the Pointed/SAM domain) and
are thus distinguished in sub-families (1). ERG belongs
to the Erg/Fli-1 sub-family. It has been widely studied
for its involvement in human cancers; TMPRSS2-ERG
fusion, which occurs on account of translocations
and interstitial deletions, is implicated in
aggressive forms of prostate cancer (4, 5). ERG is linked
to normal processes such as mesoderm formation and is
found to form functional complexes with Jun/Fos, with
the resulting ternary complexes regulating expression
of genes such as metalloprotease-1 (MMP-1) and MMP-3 (1).
It may also participate in transcriptional
regulation through the recruitment of SETDB1
histone methyltransferase and subsequent modification
of local chromatin structure (2).


Recommended Applications

ICC
Applications and Recommended Dilution Factors

ICC: 1:50 - 100
Species Reactivity

Human

Products Data

Immunofluorescent analysis of LnCaP cells using
anti-ERG RabMAb (DyLight® 488 conjugate,
cat.# 4583-1) (green) and dapi (blue).

Specificity

A synthetic peptide corresponding to residues on
the C-terminus in human ERG was used as an immunogen.
This antibody also detects Fli-1.
性状 【反应特异性】Human
【克隆 ID】EPR3864
【用途】ICC
【抗原分子量】55kDa
贮存 Storage Condition and Buffer Store at 2-8° C. PBS (pH 7.2), 0.02% sodium azide, 0.05% BSA. Protect from light. Stable for 6 months from date of receipt.
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