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FAK Rabbit Antibody

英文名：Rabbit Monoclonal IgG
Cas号：
检测信息查询
货号 规格 货期 库存 价格 会员价 订购
1308113576-100ul 现货 0 ￥0
- +
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别 名 FADK 1, pp125FAK, Protein-tyrosine kinase 2
Cas号
M D L
分子式
分子量
产品参数 【产品介绍】Focal adhesion kinase (FAK) is a non-recept
o r protein-tyrosine kinase implicated in signaling
pathways involved in cell motility, proliferation
a n d apoptosis (1). FAK is composed of a central
catalytic domain flanked by large N- a n d
C-terminal regions. FAK is activated by phosph o r
ylation at tyrosine 397 in response to integrin
clustering which can be induced by cell adhesion
o r antibody cross-linking o r via G-protein-coupled
recept o r (GPCR) occupancy by lig a n d s such as
bombesin o r lysophosphatidic acid (2-3). Phosph o r
ylation of FAK Tyr-397 c r e a t e s a binding site
f o r Src-family kinases, a n d phosph o r ylation of
FAK Tyr-576/Tyr-577 in the kinase domain activation
loop enhances catalytic activity (4). Increased
FAK expression has been c o r related with the
enhanced motility a n d invasiveness of human tum o r
cells, as well as with promoting increased
cell proliferation (5).


WB: 1:500 2000
IHC: 1:100 250
ICC: 1:100 250
Flow Cytometry: 1:30


A. Western blot analysis on HeLa cell lysate using
anti-FAK1 RabMAb (cat. # 2146-1), dilution 1:500.


B. Immunohistochemical staining of paraffin-embedded
human tonsils using anti-FAK RabMAb (cat. #2146-1).
性状 【反应特异性】Human , Mouse , Rat
【克隆 ID】EP1831Y
【用途】WB , IHC , ICC , FC
【抗原分子量】125 kDa
贮存
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