FKBP6

英文名:Rabbit Monoclonal Antibody
Cas号:
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别 名 FKBP6 antibody, FKBP36 antibody, MGC87179 antibody, PPIase antibody, Peptidyl-prolyl cis-trans isomerase FKBP6 antibody, Immunophilin FKBP36 antibody, Rotamase antibody
Cas号
M D L
分子式
分子量
产品参数 【产品介绍】FK506 binding protein 6 (FKBP6) is a
cellular receptor for the immunosuppressants FK506
and rapamycin in the immunophilin FKBP family (1).
FKBP's are involved in several biochemical
processes including protein folding, receptor
signaling, protein trafficking and transcription (2).
It forms a complex as FKBP-FK506 to competitively bind
to and inhibit the Calcium- and
calmodulin-dependent phosphatase calcineurin (3).
FKBP6 plays a role in sex-specific fertility as a
component of the synaptonemal complex, which is
essential for chromosome pairing and meiotic division (4).
A genetic deletion in FKBP6 is associated with
Williams-Beuren syndrome (WBS), a
neurodevelopmental disorder (5).


Recommended Applications

WB, IHC, FC
Applications and Recommended Dilution Factors

WB: 1:1,000 - 10,000
IHC: 1 : 100 -250
FC: 1 : 10 -100
Species Reactivity

Human, Mouse, Rat

Products Data

Western blot analysis on (A) Molt-4 and (B) SAOS-2
cell lysates using anti-FKBP6 RabMAb (cat. # 2850-1).

Immunohistochemical analysis of paraffin-embedded
human tonsil tissue using anti-FKBP6 RabMAb (cat. #2850-1).

Specificity

A synthetic peptide corresponding to residues near
the C-terminus in human FKBP6 was used as an immunogen.
性状 【反应特异性】Human , Mouse , Rat
【克隆 ID】EPR3674
【用途】WB , IHC , FC
【抗原分子量】38kDa
贮存 Storage Condition and Buffer Store at -20 °C. Buffer: 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA. Stable for 12 months from date of receipt.
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