Gab1 Phospho (pY627)

英文名:Rabbit Monoclonal IgG
Cas号:
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别 名 GRB2-associated binder 1
Cas号
M D L
分子式
分子量
产品参数 【产品介绍】Gab1 (Grb2-associated binder-1) is an adapt
o r protein that serves to activate numerous
intracellular signaling pathways via its interaction
with recept o r tyrosine kinases (RTKs). Gab1 is a
substrate of various RTKs, including EGFR, insulin recept
o r , cytokine recept o r s, a n d B cell antigen recept
o r s; a n d it acts as a docking protein f o r
several SH2-containing proteins (1-3). Tyrosine-phosph
o r ylated Gab1 may recruit cytosolic signaling proteins
to the cellular membrane, where they can act
on membrane-bound targets as well as activate
downstream pathways (4).


WB: 1:1000
IHC: 1:250
IP: 1:50


A. Western blot analysis of immunoprecipitation
pellets using (A) serum starved 293 cell lysate o r
(B) serum starved 293 cell lysate + insulin in the
presence of anti-Phospho-Gab1 (pY627) RabMAb
(catalog #1128-1), dilution.: 1:50


B. Immunohistochemical analysis of paraffin-
embedded hepatocellular carcinoma using
anti-Phospho- Gab1(pY627) RabMAb(catalog #1128-1).


C. Dot Blot analysis on immunogen phospho-peptide (A)
a n d non-phospho peptide (B) uding
anti-Phospho-Gab1 (pY627) RabMAb (catalog #1128-1),
dilution 1:1,000.
性状 【反应特异性】Human
【克隆 ID】E128
【用途】WB , IHC , IP
【抗原分子量】105 kDa
贮存
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