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Alpha-Actinin 3
英文名：Rabbit Monoclonal Antibody
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检测信息查询
| 货号 | 规格 | 货期 | 库存 | 价格 | 会员价 | 订购 |
| 1308114364-100ul | 现货 | 0 | ￥1716 | 请登录 |
| 别 名 | ACTN3, Alpha-actinin-3, Alpha-actinin skeletal muscle isoform 3, F-actin cross-linking protein |
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| 产品参数 | 【产品介绍】The alpha-actinins are a multigene family
of four actin-binding proteins related to dystrophin. The two skeletal muscle isoforms of alpha-actinin, ACTN2 and ACTN3, are major structural components of the Z-line involved in anchoring the actin-containing thin filaments. In humans, ACTN2 is expressed in all muscle fibers, while ACTN3 expression is restricted to a subset of type 2 fibers. Absence of alpha-actinin-3 is not associated with an obvious disease phenotype, raising the possibility that ACTN3 is functionally redundant in humans, and that alpha-actinin-2 is able to compensate for alpha-actinin-3 deficiency (1). Alpha-Actinin-3 is specifically expressed in fast-twitch myofibers responsible for generating force at high velocity. The absence of a disease phenotype secondary to alpha-actinin-3 deficiency is likely due to compensation by the homologous protein, alpha-actinin-2. However, the high degree of evolutionary conservation of ACTN3 suggests function(s) independent of ACTN2. Highly significant associations between ACTN3 genotype and athletic performance have been demonstrated in both male and female athletes. Recommended Applications WB Applications and Recommended Dilution Factors WB IHC ICC FC IP 1:1,000 - 10,000 Species Reactivity* Human Mouse Rat Positive Positive Positive Western blot analysis on (A) human skeletal muscle, (B) mouse skeletal muscle, and (C) rat skeletal muscle lysates using anti-Alpha-Actinin 3 RabMAb (cat. # 2952-1). Specificity A synthetic peptide corresponding to residues in human Alpha-Actinin 3 was used as an immunogen. |
| 性状 | 【反应特异性】Human , Mouse , Rat 【克隆 ID】EPR2532
【用途】WB 【产品性状】 【阳性对照】 【产品浓度】 【细胞定位】 【抗原分子量】100 kDa |
| 贮存 | Store at -20 °C. Buffer: 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA. Stable for 12 months from date of receipt. |
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