Alpha-Actinin 4

英文名:Alpha-Actinin 4
Cas号:
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别 名 ACTN4, Alpha-actinin-4, Non-muscle alpha-actinin 4, F-actin cross-linking protein
Cas号
M D L
分子式
分子量
产品参数 【产品介绍】Alpha-actinin is a ubiquitously
expressed cytoskeletal protein found in numerous
actin structures. It consists of an N-terminal
actin-binding domain, a central rod domain, and a
C-terminal domain; the protein functions as a homodimer
to cross-link actin filaments. The rod domain determines
the distance between cross-linked actin filaments and
also serves as an interaction site for several
cytoskeletal and signaling proteins (1). Alpha-actinin 4
is a non-muscle isoform version of alpha-actinin that
is concentrated in the cytoplasm (2). It plays a role
in cell motility, invasion, and metastasis of cancer
cells (3). Alpha-actinin 4 is commonly expressed
in filopodia, lamellipodia, stress fibers, and sites
of adhesion (4).

Recommended Applications
WB, IHC, ICC, IP
Applications and Recommended Dilution Factors

WB IHC ICC FC IP
1:1,000 - 10,000 1:100 - 250 1:100 - 250 1:10 - 100

Species Reactivity*

Human Mouse Rat
Positive Positive Positive

Product Data

Western blot analysis on (A) fetal skeletal muscle,
(B) A431, (C) MCF-7, and (D) HeLa cell lysates
using anti-Alpha-Actinin 4 RabMAb (cat. # 2885-1).

Immunohistochemical staining of paraffin-embedded
human kidney tissue using anti-Alpha-Actinin 4 RabMAb
(cat. #2885-1).

Immunofluorescent staining of HeLa cells using
anti-Actinin 4 RabMAb (cat. #2885-1).

Specificity
A synthetic peptide corresponding to residues on
the N-terminus in human Alpha-Actinin 4 was used as
an immunogen.
性状 【产品类型】Rabbit Monoclonal Antibody
【反应特异性】Human , Mouse , Rat
【克隆 ID】EPR2533(2)
【用途】WB , IHC , ICC , IP
【产品性状】
【阳性对照】
【产品浓度】
【细胞定位】
【抗原分子量】100 kDa
贮存 Store at -20 °C. Buffer: 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA. Stable for 12 months from date of receipt.
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