JAK2 Phospho (pY1007/1008)

英文名:JAK2 Phospho (pY1007/1008)
Cas号:
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别 名 Janus kinase 2, JAK-2
Cas号
M D L
分子式
分子量
产品参数 【产品介绍】Jak2 is a member of the Janus family
tyrosine kinases (Jaks), whose function is to
transduce extracellular signals from cytokines
a n d interferons. Jaks associate with cytokine recept
o r s; upon lig a n d binding, Jaks phosph o r ylate
the recept o r . The phosph o r ylated recept o r s
are bound by SH2-containing proteins, one class of which
is the signal transducers a n d activat o r s
of transcription (STATs). Activated STATs, then,
translocate to the nucleus to mediate gene
transcription (1,2). Tyr1007/1008 of Jak2 are the
homologous Tyr1054/1055 in Tyk2, a n d phosph o r ylation
at these residues is needed f o r Tyk2 activation (3).
A chromosomal aberration involving Jak2 is found in a
f o r m of pre-B acute myeloid leukemia (4).

WB: 1:5,000-10,000
IHC: 1:50-100
ICC: 1:50100
IP: 1:50

A. Western blot analysis of immunoprecipitation pellets
from Jurkat cell lysate +GM-CSF (catalog #1477-1),
dilution 1:50.

B. Immunohistochemical analysis of paraffin-embedded
human lung adenocarcinoma using anti-JAK-2
(pY1007/1008) RabMAb (catalog #1477-1).

C. Dot Blot analysis on immunogen phospho-peptide (A)
a n d non-phospho peptide (B) using anti-Jak2
(pY1007/1008) RabMAb (cat. # 1477-1) dilution 1:1,000

性状 【产品类型】Rabbit Monoclonal IgG
【反应特异性】Human , Mouse , Rat
【克隆 ID】E132
【用途】WB , IHC , ICC , IP
【产品性状】
【阳性对照】
【产品浓度】
【细胞定位】
【抗原分子量】130 kDa
贮存
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