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Recombinant Human Insulin-like Growth Factor-1
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| 性状 | Recombinant Human Insulin-like Growth Factor-1 是一种促进有丝分裂的细胞因子，与 IGF 受体结合，能够调节多种组织的生长，如神经组织、淋巴组织、生殖组织、平滑肌、内皮细胞和骨骼等，同时具有调节神经保护的作用。
Synonyms rHuIGF-1; IGF-IA; Somatamedin C; MGF; IGF-I ; 重组人胰岛素样生长因子-1 Species Human Source E. coli Accession P05019 Gene ID 3479 Molecular Weight Approximately 7.7 kDa AA Sequence GPETLCGAEL VDALQFVCGD RGFYFNKPTG YGSSSRRAPQ TGIVDECCFR SCDLRRLEMY CAPLKPAKSA Biological Activity The ED50 is <5 ng/mL as measured by FDC-P1 cells, corresponding to a specific activity of >2.0 × 105 units/mg. Appearance Lyophilized powder. Formulation Lyophilized after extensive dialysis against PBS. Endotoxin Level <0.2 EU/μg, determined by LAL method. Reconstitution Reconstitute the lyophilized recombinant Human Insulin-like Growth Factor-1 (rHuIGF-1) to 100 µg/mL using ddH2O. Storage & Stability Lyophilized recombinant Human Insulin-like Growth Factor-1 (rHuIGF-1) is stored at -20°C. After reconstitution, it is stable at 4°C for 2 weeks or -20°C for longer. It is recommended to freeze aliquots at -20°C or -80°C for extended storage. Shipping Room temperature in continental US; may vary elsewhere. Background Insulin-like growth factor (IGF) system has been shown to modulate growth in many tissues, such as nervous tissue, lymphoid tissue, reproductive tissue, smooth muscle, endothelium, and bone. Insulin-like Growth factor-1 (IGF-I) is produced by osteoblasts, and its mitogenic effects are mediated by their binding to the IGF plasma membrane receptors. The IGF type 1 receptor binding to both IGF-I and IGF-II, is thought to be the predominate receptor involved in mediating the effects of these growth factors in most cell types, including osteoblasts[1]. Insulin-like growth factor-1 (IGF-1) is a neurotrophic factor capable of mediating neuroprotective and neuroplasticity mechanisms. Targeted overexpression of IGF-1 enhances the generation of hippocampal newborn neurons in brain-injured mice[2]. |
| 贮存 |
- Recombinant Human Granulocyte-Macrophage Colony Stimulating Factor(CHO-expressed)
- Recombinant Human Granulocyte-Macrophage Colony Stimulating Factor
- Recombinant Human Granulocyte-Macrophage Colony Stimulating Factor(P.pastoris-expressed)
- Recombinant Human Heparin-binding EGF-like Growth Factor
- Recombinant Human Insulin-like Growth Factor-1
- Recombinant Human Insulin-like Growth factor-2
- Recombinant Human Insulin-like Growth Factor-Binding Protein 3
- Recombinant Human Insulin-like Growth Factor-Binding Protein 5
- Recombinant Human Interferon-alpha2a
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