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Recombinant Human CD19, Fc Chimera (CHO-expressed)

英文名：
Cas号：
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货号 规格 货期 库存 价格 会员价 订购
1308132846-10 μg 0 ￥3800 请登录
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1308132846-50 μg 0 ￥8400 请登录
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别 名
Cas号
M D L
分子式
分子量
产品参数
性状 Recombinant Human CD19, Fc Chimera (CHO-expressed) 是在 CHO 中产生的 C-末端标记 IgG1 Fc 片段的多肽链。CD19 是正常和肿瘤 B 细胞的生物标志物。
Synonyms
rHuCD19, Fc Chimera; B-lymphocyte surface antigen B4; T-cell surface antigen Leu-12
Species
Human

Source
CHO

Accession
P15391

Gene ID
930

Molecular Weight
Approximately 62 kDa

AA Sequence
PEEPLVVKVE EGDNAVLQCL KGTSDGPTQQ LTWSRESPLK PFLKLSLGLP GLGIHMRPLA IWLFIFNVSQ QMGGFYLCQP GPPSEKAWQP GWTVNVEGSG ELFRWNVSDL GGLGCGLKNR SSEGPSSPSG KLMSPKLYVW AKDRPEIWEG EPPCLPPRDS LNQSLSQDLT MAPGSTLWLS CGVPPDSVSR GPLSWTHVHP KGPKSLLSLE LKDDRPARDM WVMETGLLLP RATAQDAGKY YCHRGNLTMS FHLEITARPV LWHWLLRTGG WK

Appearance
Lyophilized powder.

Formulation
Lyophilized after extensive dialysis against PBS.

Endotoxin Level
<0.2 EU/μg, determined by LAL method.

Reconstitution
Reconstitute the lyophilized recombinant Human CD19, Fc Chimera (CHO-expressed) (rHuCD19, Fc Chimera) to 100 µg/mL using ddH2O or diluted with PBS.

Storage & Stability
Lyophilized recombinant Human CD19, Fc Chimera (CHO-expressed) (rHuCD19, Fc Chimera) is stored at -20°C. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer. It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Shipping
Room temperature in continental US; may vary elsewhere.

Background
CD19 is classified as a type I transmembrane protein, with a single transmembrane domain, a cytoplasmic C-terminus, and extracellular N-terminus. CD19 is a biomarker for normal and neoplastic B cells, as well as follicular dendritic cells. CD19 is critically involved in establishing intrinsic B cell signaling thresholds through modulating both B cell receptor-dependent and independent signaling. CD19 functions as the dominant signaling component of a multimolecular complex on the surface of mature B cells, alongside complement receptor CD21, and the tetraspanin membrane protein CD81 (TAPA-1), as well as CD225. Through study of CD19 transgenic and knockout mouse models, it becomes clear that CD19 plays a critical role in maintaining the balance between humoral, antigen-induced response and tolerance induction[1].
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