Recombinant Human Apolipoprotein A-I

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Cas号:
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分子式
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产品参数
性状 Recombinant Human Apolipoprotein A-I 在大肠杆菌 (E. coli) 中表达。Apolipoprotein A-I (ApoA-I) 是高密度脂蛋白 (HDL) 的主要蛋白成分,在胆固醇反向转运途径中起关键作用。Apolipoprotein A-I (ApoA-I) 与登革热病毒 (DV) 颗粒相关,并通过 SR-BI 增强病毒感染。
Synonyms
rHuApolipoprotein A-I; ApoA1; Apolipoprotein A-I
Species
Human

Source
E. coli

Accession
P02647

Gene ID
335

Molecular Weight
27-29 kDa

AA Sequence
RHFWQQDEPP QSPWDRVKDL ATVYVDVLKD SGRDYVSQFE GSALGKQLNL KLLDNWDSVT STFSKLREQL GPVTQEFWDN LEKETEGLRQ EMSKDLEEVK AKVQPYLDDF QKKWQEEMEL YRQKVEPLRA ELQEGARQKL HELQEKLSPL GEEMRDRARA HVDALRTHLA PYSDELRQRL AARLEALKEN GGARLAEYHA KATEHLSTLS EKAKPALEDL RQGLLPVLES FKVSFLSALE EYTKKLNTQ

Biological Activity
Data is not available.

Appearance
Lyophilized powder.

Formulation
Lyophilized after extensive dialysis against 20 mM PB, 150 mM NaCl, pH 7.4.

Endotoxin Level
<1 EU/μg, determined by LAL method.

Reconstitution
Reconstitute the lyophilized recombinant Human Apolipoprotein A-I (rHuApolipoprotein A-I) to 100 µg/mL using ddH2O or diluted with PBS.

Storage & Stability
Lyophilized recombinant Human Apolipoprotein A-I (rHuApolipoprotein A-I) is stored at -20°C. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer. It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Shipping
Room temperature in continental US; may vary elsewhere.

Background
Apolipoprotein A1 (ApoA1) is a 28 kDa glycoprotein that is the major protein component of high density lipoprotein (HDL) particles. HDL particles play a central role in the reverse transport of cholesterol from peripheral tissues to the liver. In the past decade, reconstituted HDL (rHDL) has been employed as a therapeutic agent for treatment of atherosclerosis. The ability of rHDL to promote cholesterol efflux from peripheral cells has been documented to reduce the size of atherosclerotic plaque lesions[2].
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