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CaMKII (CAMK2B)
英文名：Rabbit Monoclonal Antibody
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检测信息查询
| 货号 | 规格 | 货期 | 库存 | 价格 | 会员价 | 订购 |
| 1308113391-100ul | 现货 | 0 | ￥0 | 请登录 |
| 别 名 | CAMK2B antibody, CAM2 antibody, CAMK2 antibody, CAMKB antibody, MGC29528 antibody, Calcium/calmodulin-dependent protein kinase type II subunit beta antibody, antibody |
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| 产品参数 | 【产品介绍】Calcium/calmodulin-dependent protein kinase
II (CaMKII) is a widely distributed protein kinase that regulates numerous physiological functions. Inhibitors of CaMKII are useful tools for investigating the CaMKII functions (1). The synapse contains densely localized and interacting proteins that enable it to adapt to changing inputs. A Ca2+-sensitive protein complex is involved in the regulation of AMPA receptor synaptic plasticity. The complex is comprised of MUPPI, a multi-PDZ domain-containing protein; SynGAP, a synaptic GTPase-activating protein; and the Ca2+/calmodulin-dependent kinase CaMKII. In synapses of hippocampal neurons, SynGAP and CaMKII are brought together by direct physical interaction with the PDZ domains of MUPP1, and in this complex, SynGAP is phosphorylated. Ca2+CaM binding to CaMKII dissociates it from the MUPP1 complex, and Ca2+ entering via the NMDAR drives the dephosphorylation of SynGAP (2). Recommended Applications WB, FC Applications and Recommended Dilution Factors WB: 1:1,000 - 10,000 FC: 1:10 - 100 Species Reactivity * Human, Mouse, Rat *Species cross-reactivity is based on WB analysis. Products Data Western blot analysis on (A) human pancreas, (B) fetal kidney, (C) HeLa, (D) Jurkat, (E) SH-SY5Y, (F) BxPC-3, and (G) C6 lysates using anti-CaMKII RabMAb (cat. #5475-1). Flow cytometric analysis of permeabilized C6 cells using anti-CaMKII RabMAb (red) (catalog # 5475-1) or a rabbit IgG (negative) (green). Specificity A synthetic peptide corresponding to residues in human CaMKII was used as an immunogen. Storage Condition and Buffer Store at -20° C. Buffer: Antibody buffer, sodium azide, glycerol, and BSA. Stable for 12 months from date of receipt. |
| 性状 | 【反应特异性】Human , Mouse , Rat
【克隆 ID】EPR6685(B) 【用途】WB , FC 【抗原分子量】45 - 70kDa |
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