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Caspase-2

英文名：Rabbit Monoclonal IgG
Cas号：
检测信息查询
货号 规格 货期 库存 价格 会员价 订购
1308113400-100ul 现货 0 ￥0
- +
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别 名 CASP-2, ICH-1 protease, NEDD2 protein, Neural precurs o r cell expressed developmentally down-regulated protein 2, NEDD-2
Cas号
M D L
分子式
分子量
产品参数 【产品介绍】Caspase-2 (Nedd2/ICH-1) is part of a family
of aspartate-specific cysteine proteases that participate
in programmed cell death, o r apoptosis. Caspase-2
is localized to the nucleus, a n d has been shown to
play roles in both positive a n d negative regulation
of apoptosis (1). Upon apoptotic stimulation,
pro-caspase-9 is cleaved in a series of steps to produce
an 18-kDa large subunit a n d a 12-kDa small fragment
(2). Caspase-2 can be a nuclear initiat o r caspase, as
it has been shown to precede the processing a n d
activation of caspase-8, -9, a n d -3 (3). Caspase-2
might also act as an effect o r caspase; in
apoptotic pathways resulting from UV-induced DNA
damage, processing of caspase-2 occurs downstream
of caspase-9 a n d caspase-3 activation (4).


WB: 1:500
IP: 1:20


A. Western blot analysis on Jurkat cell lysate
using anti-Caspase-2 RabMAb (catalog #1552-1),
dilution 1:500.
性状 【反应特异性】Human
【克隆 ID】Y154
【用途】WB , IP
【抗原分子量】48/18 kDa
贮存
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