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CD205 (LY75)

英文名：Rabbit Monoclonal Antibody
Cas号：
检测信息查询
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别 名 LY75 antibody, CD205 antibody, CLEC13B antibody, DEC-205 antibody, GP200-MR6 antibody, LY-75 antibody, Lymphocyte antigen 75 antibody, C-type lectin domain family 13 member B antibody, DEC-205 antibody, gp200-MR6 antibody
Cas号
M D L
分子式
分子量
产品参数 【产品介绍】CD205 is a type I C-type lectin-like
molecule that acts as an endocytic receptor to
direct captured antigens from the extracellular space to
a specialized antigen-processing compartment (1, 2).
It functions to deliver antigen to dendritic cells
for presentation on MHC class II and cross-presentation
on MHC class I. Thus, CD205 plays an important role in
CD4 and CD8 T cell tolerance induction to self-antigen
both in the periphery and in the thymus. It is expressed
at high levels on cortical thymic epithelium,
thymic medullary DCs (CD11c+ CD8+), and subsets
of peripheral DCs (CD11c+ CD8+ splenic/lymph node
DCs, dermal/interstitial DCs, and Langerhans cells) (2).
In addition, CD205 causes reduced proliferation
of B-lymphocytes (1).


Recommended Applications

WB, IHC, ICC, IP
Applications and Recommended Dilution Factors

WB: 1:1,000 - 10,000
IHC: 1:250 - 500
ICC: 1:100 - 250
IP: 1:10 - 100
Species Reactivity *

Human, Mouse

*Species cross-reactivity is based on WB analysis


Products Data

Western blot analysis on (A) human thymus, (B) human
lymph node, (C) human tonsil, and (D) mouse thymus
lysates using anti-CD205 RabMAb (cat. #3912-1).


Immunohistochemical analysis of paraffin-embedded
human tonsil tissue using anti-CD205 RabMAb (cat. #3912-1).


Specificity

A synthetic peptide corresponding to residues in
the intracellular domain of human CD205 was used
as an immunogen.

性状 【反应特异性】Human , Mouse
【克隆 ID】EPR5233
【用途】WB , IHC , ICC , IP
【抗原分子量】205kDa
贮存 Storage Condition and Buffer Store at -20 °C. Antibody buffer, 0.01% sodium azide, 50% Glycerol and 0.05% BSA. Stable for 12 months from date of receipt
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