【产品介绍】CD276 is a single-pass type I membrane
protein that modulates T-cell-mediated immune responses
and the development of acute and chronic
transplant rejection. It plays a positive regulatory role
in bone formation and has a dual role in the
bone-immune interface (1). CD276 has been shown to
impair type 1 T-helper cell responses and inhibit
cytokine production (2). Furthermore, it induces
antitumor immunity as it activates both acquired and
innate immunity leading to natural killer cell and
CD8 T-cell dependent killing of tumor cells (1).
Recommended Applications
WB, IP, FC
Applications and Recommended Dilution Factors WB: 1:1,000 - 10,000
IP: 1:10 - 100
FC: 1:10 - 100
Species Reactivity * Human, Mouse *Species cross-reactivity is based on WB analysis.
Products Data
Western blot analysis on (A) 293T, (B) LnCaP, and (C)
JAR cell lysates using anti-CD276 RabMAb (cat. #5134-1). Western blot analysis on CD276 knockout CHO cell
lysates, (A) untransfected or (B) transfected with
CD276 using anti-CD276 RabMAb (cat.# 5134-1).
Specificity
Human CD276 recombinant protein and CD276
over-expressing CHO cells were used as an immunogen. This antibody was developed as part of a
collaboration between Epitomics, the National
Cancer Institute's Center for Cancer Research and the lab
of Brad St. Croix. |
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