Recombinant Human MIP-1 beta/CCL4 是一种促趋化因子,既能够在各种炎症条件下促进白细胞聚集,又有助于对人类免疫缺陷 1 型病毒产生免疫保护 Synonyms rHuMIP-1β/CCL4; C-C motif chemokine 4; LAG-1; Macrophage inflammatory protein 1-beta; SCYA4 ; 重组人 MIP-1 beta/CCL4 Species HumanSource E. coli Accession P13236 Gene ID 6351 Molecular Weight Approximately 7.6 kDa AA Sequence APMGSDPPTA CCFSYTARKL PRNFVVDYYE TSSLCSQPAV VFQTKRSKQV CADPSESWVQ EYVYDLELN Biological Activity The ED50 is <100 ng/mL as measured by CHO-K1/Gα15/hCCR5 cells (human Gα15 and human CCR5 stably expressed in CHO-K1 cells). Appearance Lyophilized powder. Formulation Lyophilized after extensive dialysis against PBS. Endotoxin Level <0.2 EU/μg, determined by LAL method. Reconstitution Reconstitute the lyophilized recombinant Human MIP-1 beta/CCL4 (rHuMIP-1β/CCL4) to 100 μg/mL using ddH2O or PBS. Storage & Stability Lyophilized recombinant Human MIP-1 beta/CCL4 (rHuMIP-1β/CCL4) is stored at -20°C. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer. It is recommended to freeze aliquots at -20°C or -80°C for extended storage. Shipping Room temperature in continental US; may vary elsewhere. Background Human macrophage inflammatory protein-1 (MIP-1β) 1 is a proinflammatory chemokine that both promotes leukocyte accumulation in various inflammatory conditions and contributes to protective immunity against human immunodeficiency virus type 1 (HIV-1) (1-5)[1]. |