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Recombinant Human Interleukin-19
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| 性状 | Recombinant Human Interleukin-19是白细胞介素-10家族的成员。 Recombinant Human Interleukin-19的生物学功能和临床意义仍待研究。
Synonyms rHuIL-19; Melanoma differentiation association like protein; ZMDA1 ; 重组人白细胞介素-19 Species Human Source E. coli Accession Q9UHD0 Gene ID 29949 Molecular Weight Approximately 17.9 kDa AA Sequence LRRCLISTDM HHIEESFQEI KRAIQAKDTF PNVTILSTLE TLQIIKPLDV CCVTKNLLAF YVDRVFKDHQ EPNPKILRKI SSIANSFLYM QKTLRQCQEQ RQCHCRQEAT NATRVIHDNY DQLEVHAAAI KSLGELDVFL AWINKNHEVM SSA Biological Activity The ED50 is <1.5 ng/mL as measured by murine BaF3 pro-B cells, corresponding to a specific activity of >6.7 × 105 units/mg. Appearance Lyophilized powder. Formulation Lyophilized after extensive dialysis against PBS, pH 7.4. Endotoxin Level <1 EU/μg, determined by LAL method. Reconstitution Reconstitute the lyophilized recombinant Human Interleukin-19 (rHuIL-19) to 0.1-1.0 mg/mL using sterile distilled water or aqueous buffer containing 0.1% BSA. Storage & Stability Lyophilized recombinant Human Interleukin-19 (rHuIL-19) is stored at -20°C. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer. It is recommended to freeze aliquots at -20°C or -80°C for extended storage. Shipping Room temperature in continental US; may vary elsewhere. Background IL-19 shares 21% amino acid identity with IL-10. The exon/intron structure of IL-19 is similar to that of the human IL-10 gene, comprising five exons and four introns within the coding region of the IL-19 cDNA. IL-19 does not bind or signal through the canonical IL-10 receptor complex[1]. IL-19 functions through a receptor complex composed of IL-20Ra and IL20Rb that is also utilized by IL-20 and IL-24. IL19 has been shown to enhance the production of Th2 cytokines in Tcells and to be elevated in asthma patients. Furthermore, it induces IL-6, IL-8 and IL-10 expression in monocytes. Additionally, it has been implicated in a range of diseases and disorders, including aging, Type-I diabetes, endotoxic shock, periodontal disease, vascular disease and rheumatoid arthritis[2]. |
| 贮存 |
- Recombinant Mouse Interleukin-12 (CHO-expressed)
- Recombinant Human Interleukin-17F
- Recombinant Rat Interleukin-18
- Recombinant Human Interleukin-18 Binding Protein (CHO-expressed)
- Recombinant Human Interleukin-19
- Recombinant Mouse Interleukin-19
- Recombinant Human Interleukin-20
- Recombinant Human Interleukin-2 Receptor alpha, His (HEK293-expressed)
- Recombinant Canine Interleukin-3
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