Recombinant Mouse Interleukin-19

英文名:
Cas号:
检测信息查询
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1308132726-10 μg 0 ¥3800 请登录
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1308132726-50 μg 0 ¥8400 请登录
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别 名
Cas号
M D L
分子式
分子量
产品参数
性状 Recombinant Mouse Interleukin-19是白细胞介素-10家族的成员。 Recombinant Human Interleukin-19的生物学功能和临床意义仍待研究。
Synonyms
rMuIL-19; IL19 ; 重组小鼠白细胞介素-19
Species
Mouse

Source
E. coli

Accession
Q8CJ70

Gene ID
329244

Molecular Weight
Approximately 17.7 kDa

AA Sequence
MLRRCLISVD MRLIEKSFHE IKRAMQTKDT FKNVTILSLE NLRSIKPGDV CCMTNNLLTF YRDRVFQDHQ ERSLEVLRRI SSIANSFLCV QKSLERCQVH RQCNCSQEAT NATRIIHDNY NQLEVSSAAL KSLGELNILL AWIDRNHLET PAA

Biological Activity
The ED50 is <50 ng/mL as measured by MCF-7 cells, corresponding to a specific activity of >2.0 × 104 units/mg.

Appearance
Lyophilized powder.

Formulation
Lyophilized after extensive dialysis against 50 mM acetic acid.

Endotoxin Level
<0.2 EU/μg, determined by LAL method.

Reconstitution
Reconstitute the lyophilized recombinant Mouse Interleukin-19 (rMuIL-19) to 50 μg/mL using 50 mM acetic acid.

Storage & Stability
Lyophilized recombinant Mouse Interleukin-19 (rMuIL-19) is stored at -20°C. After reconstitution, it is stable at 4°C for 2 weeks or -20°C for longer. It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Shipping
Room temperature in continental US; may vary elsewhere.

Background
IL-19 shares 21% amino acid identity with IL-10. The exon/intron structure of IL-19 is similar to that of the human IL-10 gene, comprising five exons and four introns within the coding region of the IL-19 cDNA. IL-19 does not bind or signal through the canonical IL-10 receptor complex[1]. IL-19 functions through a receptor complex composed of IL-20Ra and IL20Rb that is also utilized by IL-20 and IL-24. IL19 has been shown to enhance the production of Th2 cytokines in Tcells and to be elevated in asthma patients. Furthermore, it induces IL-6, IL-8 and IL-10 expression in monocytes. Additionally, it has been implicated in a range of diseases and disorders, including aging, Type-I diabetes, endotoxic shock, periodontal disease, vascular disease and rheumatoid arthritis[2].
贮存
本网站销售的所有产品仅用于工业应用或者科学研究等非医疗目的,不可用于人类或动物的临床诊断或者治疗,非药用,非食用。
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