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Recombinant Human Interleukin-20

英文名：
Cas号：
检测信息查询
货号 规格 货期 库存 价格 会员价 订购
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1308132727-50 μg 0 ￥12400 请登录
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别 名
Cas号
M D L
分子式
分子量
产品参数
性状 Recombinant Human Interleukin-20是IL-10细胞因子家族的成员。 Recombinant Human Interleukin-20与IL-20异二聚体受体结合，Kd 值为 1.5 nM。
Synonyms
rHuIL-20; IL20; Cytokine Zcyto10 ; 重组人白细胞介素-20
Species
Human

Source
E. coli

Accession
Q9NYY1

Gene ID
50604

Molecular Weight
Approximately 17.6 kDa

AA Sequence
MLKTLNLGSC VIATNLQEIR NGFSEIRGSV QAKDGNIDIR ILRRTESLQD TKPANRCCLL RHLLRLYLDR VFKNYQTPDH YTLRKISSLA NSFLTIKKDL RLCHAHMTCH CGEEAMKKYS QILSHFEKLE PQAAVVKALG ELDILLQWME ETE

Biological Activity
The ED50 is <0.5 ng/mL as measured by murine BaF3 pro-B cells, corresponding to a specific activity of >2.0 × 106 units/mg.

Appearance
Lyophilized powder.

Formulation
Lyophilized after extensive dialysis against PBS, pH 7.2, with trehalose.

Endotoxin Level
<1 EU/μg, determined by LAL method.

Reconstitution
Reconstitute the lyophilized recombinant Human Interleukin-20 (rHuIL-20) to 0.1-1.0 mg/mL using sterile distilled water or aqueous buffer containing 0.1% BSA.

Storage & Stability
Lyophilized recombinant Human Interleukin-20 (rHuIL-20) is stored at -20°C. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer. It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Shipping
Room temperature in continental US; may vary elsewhere.

Background
Overexpression of Interleukin-20 (IL-20) in transgenic (TG) mice causes neonatal lethality with skin abnormalities including aberrant epidermal differentiation. Recombinant IL-20 protein stimulates a signal transduction pathway through STAT3 in a keratinocyte cell line, demonstrating a direct action of this ligand. An IL-20 receptor is identified as a heterodimer of two orphan class II cytokine receptor subunits[1].
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