COPS5

英文名:Rabbit Monoclonal Antibody
Cas号:
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别 名 COPS5 antibody, CSN5 antibody, JAB1 antibody, MGC3149 antibody, MOV-34 antibody, SGN5 antibody, COP9 signalosome complex subunit 5 antibody, Jun activation domain-binding protein 1 antibody
Cas号
M D L
分子式
分子量
产品参数 【产品介绍】COPS5 is one of the eight subunits of
COP9 signalosome, a highly conserved protein complex
that functions as an important regulator in
multiple signaling pathways. The structure and function
of COP9 signalosome is similar to that of the 19S
regulatory particle of 26S proteasome. COP9 signalosome
has been shown to interact with SCF-type E3
ubiquitin ligases and act as a positive regulator of
E3 ubiquitin ligases. COPS5 is reported to be involved
in the degradation of cyclin-dependent kinase
inhibitor CDKN1B/p27Kip1. It is also known to be
an coactivator that increases the specificity of
JUN/AP1 transcription factors (1).


Recommended Applications

WB, IHC, ICC, IP
Applications and Recommended Dilution Factors

WB: 1:1,000 - 10,000
IHC: 1:100 - 250
ICC: 1:50 - 100
IP: 1:10 - 100
Species Reactivity *

Human, Mouse, Rat

*Species cross-reactivity is based on WB analysis.

Products Data

Western blot analysis on (A) NIH/3T3, (B) U87-MG,
(C) MCF-7, and (D) PC-12 cell lysates using
anti-COPS5 RabMAb (cat. #5156-1).

Specificity

A synthetic peptide corresponding to residues in human
COPS5 was used as an immunogen.
性状 【反应特异性】Human , Mouse , Rat
【克隆 ID】EPR1350
【用途】WB , IHC , ICC , IP
【抗原分子量】36kDa
贮存 Storage Condition and Buffer Store at -20 °C. Antibody buffer, 0.01% sodium azide, 50% Glycerol and 0.05% BSA. Stable for 12 months from date of receipt
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